Matrixyl 3000 Benefits: A Plain-English Guide

By the Peptide Cream Reviews editorial team · Updated

Matrixyl® is one of the best-known names in peptide skincare. Here is what it is, how the different versions differ, and what results are realistic.

What is Matrixyl?

Matrixyl® is a trademarked family of signal peptides. The original version is palmitoyl pentapeptide-4. Matrixyl® 3000 is a newer blend of two peptides, palmitoyl tripeptide-1 and palmitoyl tetrapeptide-7. The "palmitoyl" part is a fatty acid attached to help the peptide stay in the skin.

What the research shows

A 12-week, placebo-controlled study of palmitoyl pentapeptide (Robinson et al., International Journal of Cosmetic Science, 2005) reported improvements in the appearance of fine lines and wrinkles. Matrixyl® 3000 is supported mainly by manufacturer studies. As with most cosmetic peptides, the evidence is encouraging but smaller than for retinoids.

How to use Matrixyl

  • Use it daily, morning and/or night; it is not sun-sensitive.
  • Pair it with hydrators and barrier lipids for the best feel.
  • It can be layered with retinol, niacinamide and vitamin C.
  • Give it 8 to 12 weeks.

Creams with Matrixyl®

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Frequently asked questions

What is Matrixyl 3000 made of?

Two signal peptides: palmitoyl tripeptide-1 and palmitoyl tetrapeptide-7.

Is Matrixyl better than retinol?

Retinol has stronger evidence, but Matrixyl is much gentler. Many people use both, or choose Matrixyl if retinol irritates them.

Can Matrixyl be used around the eyes?

Yes, it is common in eye creams, including the Revitol Eye Cream.